|
KMID : 0613820020120020208
|
|
Journal of Life Science
2002 Volume.12 No. 2 p.208 ~ p.212
|
|
|
Effect of Neighbor Base Sequences on the Base Pair Stabilities at d(CXG) and d(GXC) in Human ε-globin Promoter
|
|
Chung In-Ae
Gang Jong-Back
|
|
|
Abstract
|
|
|
|
Human ε-globin DNA fragment was used to determine the thermal stabilities of base pairs at d(CXG) and d(GXC) by Temperature Gradient Gel Electrophoresis(TGGE). The base pair stability depends on the hydrogen bonding interaction and base stacking interaction of neighbor base sequence. The orders of base pair stabilities were TㆍAGㆍA = AㆍG>CㆍT>TㆍC >CㆍA>AㆍC for d(GXC)ㆍd(GYC).
|
|
|
KEYWORD
|
|
|
base pair stability, Mutation detection, Temperature Gradient Gel Electrophoresis(TGGE).
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|